Train drivers will launch an overtime ban ahead of a series of strikes which will cause travel chaos.
Members of Aslef are embroiled in a 20-month dispute over jobs with no sign of a breakthrough and no plans for any talks.
Passengers are being advised to check before they travel, with some areas having no services on strike days.
The overtime ban is from Thursday to Saturday and for 48 hours from next Monday which is likely to cause delays and cancellations to services.
A strike on Friday will hit Avanti West Coast, CrossCountry, East Midlands Railway, West Midlands and London Northwestern.
On Saturday train drivers will walk out on Chiltern Railways, Great Western Railway, LNER, Heathrow Express, Northern and TransPennine Express.
A strike on Monday will affect c2c, Gatwick Express, Greater Anglia (including Stansted Express), Great Northern, Southeastern, Southern, South Western Railway (including the Island Line) and Thameslink.
Train operators warned that on strike days it is likely that little or no services will run across large areas of the network operated by the affected train companies.
Services are also likely to be disrupted and start later on the day immediately following a full strike day.
On days where an overtime ban is in place, the timetable for some train companies may be revised in advance or services subject to short-notice delay or cancellation on the day.
Passengers are warned to expect significant disruption and advised to plan ahead and check before they travel.
A law is now in place aimed at ensuring a minimum level of service during rail strikes but none of the operators involved in the Aslef dispute have applied to use it.
Aslef general secretary Mick Whelan said the union had called for talks after announcing renewed mandates for industrial action, highlighting that train drivers have not had an increase in salary since 2019.
He said: “Our members voted overwhelmingly – yet again – for strike action. Those votes show a clear rejection by train drivers of the ridiculous offer put to us in April last year by the Rail Delivery Group which knew that offer would be rejected because a land grab for all the terms and conditions we have negotiated over the years would never be accepted by our…
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